Publications

83. Strategy set-shifting and response inhibition in adult rats exposed to an environmental polychlorinated biphenyl mixture during adolescence.
Monaikul S, Eubig P, Floresco S, Schantz S.
Neurotoxicol Teratol. 2017 Sep;63:14-23. doi: 10.1016/j.ntt.2017.08.002. Epub 2017 Aug 16.

82. Persistent cognitive and morphological alterations induced by repeated exposure of adolescent rats to the abused inhalant toluene.
Braunscheidel KM, Gass JT, Mulholland PJ, Floresco SB, Woodward JJ
Neurobiol Learn Mem. 2017 Oct;144:136-146. doi: 10.1016/j.nlm.2017.07.007. Epub 2017 Jul 15.

81. Regulation of sustained attention, false alarm responding and implementation of conditional rules by prefrontal GABAAtransmission: comparison with NMDA transmission.
Auger ML, Meccia J, Floresco SB.
Psychopharmacology (Berl). 2017 Jun 24. doi: 10.1007/s00213-017-4670-1. [Epub ahead of print]

80. Prefrontal Dopamine D1and D2Receptors Regulate Dissociable Aspects of Decision Making via Distinct Ventral Striatal and Amygdalar Circuits.
Jenni NL, Larkin JD, Floresco SB.
J Neurosci. 2017 Jun 28;37(26):6200-6213. doi: 10.1523/JNEUROSCI.0030-17.2017. Epub 2017 May 25.

79. Contributions of basolateral amygdala and nucleus accumbens subregions to mediating motivational conflict during punished reward-seeking.
Piantadosi PT, Yeates DC, Wilkins M, Floresco SB.
Neurobiol Learn Mem. 2017 Apr;140:92-105. doi: 10.1016/j.nlm.2017.02.017. Epub 2017 Feb 24.

78. Deciphering Decision Making: Variation in Animal Models of Effort- and Uncertainty-Based Choice Reveals Distinct Neural Circuitries Underlying Core Cognitive Processes.
Winstanley CA, Floresco SB
J Neurosci. 2016 Nov 30;36(48):12069-12079. Review.

77. Prefrontal cortical GABAergic and NMDA glutamatergic regulation of delayed responding.
Auger ML, Floresco SB.
Neuropharmacology. 2017 Feb;113(Pt A):10-20. doi: 10.1016/j.neuropharm.2016.09.022. Epub 2016 Sep 24.

76. Dopamine Neurons, Input Integration, and Reward Prediction Errors: E Pluribus Unum.
Floresco SB.
Neuron. 2016 Sep 21;91(6):1192-1194. doi: 10.1016/j.neuron.2016.09.012.

75. Binge-Like Alcohol Exposure During Adolescence Disrupts Dopaminergic Neurotransmission in the Adult Prelimbic Cortex.
Trantham-Davidson H, Centanni SW, Garr SC, New NN, Mulholland PJ, Gass JT, Glover EJ, Floresco SB, Crews FT, Krishnan HR, Pandey SC, Chandler LJ
Neuropsychopharmacology. 2017 Apr;42(5):1024-1036. doi: 10.1038/npp.2016.190. Epub 2016 Sep 13.

74. Chronic methamphetamine self-administration alters cognitive flexibility in male rats.
Cox BM, Cope ZA, Parsegian A, Floresco SB, Aston-Jones G, See RE.
Psychopharmacology (Berl). 2016 Jun;233(12):2319-27. doi: 10.1007/s00213-016-4283-0. Epub 2016 Apr 2.

73. Multifaceted Contributions by Different Regions of the Orbitofrontal and Medial Prefrontal Cortex to Probabilistic Reversal Learning.
Dalton GL, Wang NY, Phillips AG, Floresco SB.
J Neurosci. 2016 Feb 10;36(6):1996-2006. doi: 10.1523/JNEUROSCI.3366-15.2016.

72. Perturbations in Effort-Related Decision-Making Driven by Acute Stress and Corticotropin-Releasing Factor.
Bryce CA, Floresco SB.
Neuropsychopharmacology. 2016 Jul;41(8):2147-59. doi: 10.1038/npp.2016.15. Epub 2016 Feb 2.

71. Perturbations in reward-related decision-making induced by reduced prefrontal cortical GABA transmission: Relevance for psychiatric disorders.
Piantadosi PT, Khayambashi S, Schluter MG, Kutarna A, Floresco SB.
Neuropharmacology. 2016 Feb;101:279-90. doi: 10.1016/j.neuropharm.2015.10.007. Epub 2015 Oct 9.

70. Modulation of risk/reward decision making by dopaminergic transmission within the basolateral amygdala.
Larkin JD, Jenni NL, Floresco SB.
Psychopharmacology (Berl). 2016 Jan;233(1):121-36. doi: 10.1007/s00213-015-4094-8. Epub 2015 Oct 3.

69. Neuronal Gonadotrophin-Releasing Hormone (GnRH) and Astrocytic Gonadotrophin Inhibitory Hormone (GnIH) Immunoreactivity in the Adult Rat Hippocampus.
Ferris JK, Tse MT, Hamson DK, Taves MD, Ma C, McGuire N, Arckens L, Bentley GE, Galea LA, Floresco SB, Soma KK.
J Neuroendocrinol. 2015 Oct;27(10):772-86. doi: 10.1111/jne.12307.

68. Noradrenaline and dopamine: sharing the Workload.
Floresco SB.
Trends Neurosci. 2015 Aug;38(8):465-7. doi: 10.1016/j.tins.2015.07.001. Epub 2015 Jul 14.

67. Neural mechanisms regulating different forms of risk-related decision-making: Insights from animal models.
Orsini CA, Moorman DE, Young JW, Setlow B, Floresco SB.
Neurosci Biobehav Rev. 2015 Jun 11. 58:147-67

66. Alterations in cognitive flexibility in a rat model of post-traumatic stress disorder.
George SA, Rodriguez-Santiago M, Riley J, Abelson JL, Floresco SB, Liberzon I.
Behav Brain Res. 2015 Jun 1;286:256-64. doi: 10.1016/j.bbr.2015.02.051. Epub 2015 Mar 5.

65. Prefrontal Cortical Gamma-Aminobutyric Acid Transmission and Cognitive Function: Drawing Links to Schizophrenia from Preclinical Research.
Tse MT, Piantadosi PT, Floresco SB.
Biol Psychiatry. 2015 Jun 1;77(11):929-939. doi: 10.1016/j.biopsych.2014.09.007. Epub 2014 Nov 18. Review.

64. Noradrenergic modulation of risk/reward decision making.
Montes DR, Stopper CM, Floresco SB.
Psychopharmacology (Berl). 2015 Mar 13. [Epub ahead of print]

63. Dopamine Antagonism Decreases Willingness to Expend Physical, But Not Cognitive, Effort: A Comparison of Two Rodent Cost/Benefit Decision-Making Tasks.
Hosking JG, Floresco SB, Winstanley CA.
Neuropsychopharmacology. 2015 Mar;40(4):1005-15. doi: 10.1038/npp.2014.285. Epub 2014 Oct 20.

62. Operant procedures for assessing behavioral flexibility in rats.
Brady AM, Floresco SB.
J Vis Exp. 2015 Feb 15;(96):e52387. doi: 10.3791/52387.

61. The nucleus accumbens: an interface between cognition, emotion, and action.
Floresco SB.
Annu Rev Psychol. 2015 Jan 3;66:25-52. doi: 10.1146/annurev-psych-010213-115159. Epub 2014 Sep 17.

60. Dopaminergic circuitry and risk/reward decision making: implications for schizophrenia.
Stopper CM, Floresco SB.
Schizophr Bull. 2015 Jan;41(1):9-14. doi: 10.1093/schbul/sbu165. Epub 2014 Nov 17.

59. Prefrontal Cortical GABA Modulation of Spatial Reference and Working Memory.
Auger ML, Floresco SB.
Int J Neuropsychopharmacol. 2014 Oct 31;18(2). pii: pyu013. doi: 10.1093/ijnp/pyu013.

58. Overriding Phasic Dopamine Signals Redirects Action Selection during Risk/Reward Decision Making.
Stopper CM, Tse MT, Montes DR, Wiedman CR, Floresco SB. 
Neuron. 2014 Oct 1;84(1):117-89. doi: 10.1016/j.neuron.2014.08.033.

57. Adolescent alcohol exposure reduces behavioral flexibility, promotes disinhibition, and increases resistance to extinction of ethanol self-administration in adulthood.
Gass JT, Glen WB Jr, McGonigal JT, Trantham-Davidson H, Lopez MF, Randall PK, Yaxley R, Floresco SB, Chandler LJ.
Neuropsychopharmacology. 2014 Oct;39(11):2570-83. doi: 10.1038/npp.2014.109. Epub 2014 May 13.

56. Prefrontal Cortical GABA Transmission Modulates Discrimination and Latent Inhibition of Conditioned Fear: Relevance for Schizophrenia.
Piantadosi PT, Floresco SB.
Neuropsychopharmacology. 2014 Sep;39(10):2473-84. doi: 10.1038/npp.2014.99. Epub 2014 May 2.

55. Preferential involvement by nucleus accumbens shell in mediating probabilistic learning and reversal shifts.
Dalton GL, Phillips AG, Floresco SB.
J Neurosci. 2014 Mar 26;34(13):4618-26. doi: 10.1523/JNEUROSCI.5058-13.2014.

54. Chronic alcohol disrupts dopamine receptor activity and the cognitive function of the medial prefrontal cortex.
Trantham-Davidson H, Burnett EJ, Gass JT, Lopez MF, Mulholland PJ, Centanni SW, Floresco SB, Chandler LJ.
J Neurosci. 2014 Mar 5;34(10):3706-18. doi: 10.1523/JNEUROSCI.0623-13.2014. Erratum in: J Neurosci. 2014 Apr 30;34(18):6422.

53. Sex differences in response to amphetamine in adult Long-Evans rats performing a delay-discounting task.
Eubig PA, Noe TE, Floresco SB, Sable JJ, Schantz SL.
Pharmacol Biochem Behav. 2014 Mar;118:1-9. doi: 10.1016/j.pbb.2013.12.021. Epub 2013 Dec 31.

52. Selective involvement by the medial orbitofrontal cortex in biasing risky, but not impulsive, choice.
Stopper CM, Green EB, Floresco SB.
Cereb Cortex. 2014 Jan;24(1):154-62. doi: 10.1093/cercor/bhs297. Epub 2012 Oct 4.

51. What’s better for me? Fundamental role for lateral habenula in promoting subjective decision biases.
Stopper CM, Floresco SB.
Nat Neurosci. 2014 Jan;17(1):33-5. doi: 10.1038/nn.3587. Epub 2013 Nov 24.

50. Measuring the construct of executive control in schizophrenia: defining and validating translational animal paradigms for discovery research.
Gilmour G, Arguello A, Bari A, Brown VJ, Carter C, Floresco SB, Jentsch DJ, Tait DS, Young JW, Robbins TW.
Neurosci Biobehav Rev. 2013 Nov;37(9 Pt B):2125-40. doi: 10.1016/j.neubiorev.2012.04.006. Epub 2012 Apr 23. Review.

49. Acute stress impairs set-shifting but not reversal learning.
Butts KA, Floresco SB, Phillips AG.
Behav Brain Res. 2013 Sep 1;252:222-9. doi: 10.1016/j.bbr.2013.06.007. Epub 2013 Jun 10.

48. Receptor-specific modulation of risk-based decision making by nucleus accumbens dopamine.
Stopper CM, Khayambashi S, Floresco SB.
Neuropsychopharmacology. 2013 Apr;38(5):715-28. doi: 10.1038/npp.2012.240. Epub 2012 Nov 29.

47. Prefrontal NMDA receptors and cognition: working 2B remembered.
Floresco SB.
Neuron. 2013 Feb 20;77(4):603-5. doi: 10.1016/j.neuron.2013.01.029.

46. Prefrontal dopamine and behavioral flexibility: shifting from an “inverted-U” toward a family of functions.
Floresco SB.
Front Neurosci. 2013 Apr 19;7:62. doi: 10.3389/fnins.2013.00062. eCollection 2013.

45. Dynamic fluctuations in dopamine efflux in the prefrontal cortex and nucleus accumbens during risk-based decision making.
St Onge JR, Ahn S, Phillips AG, Floresco SB.
J Neurosci. 2012 Nov 21;32(47):16880-91. doi: 10.1523/JNEUROSCI.3807-12.2012.

44. Acute stress induces selective alterations in cost/benefit decision-making.
Shafiei N, Gray M, Viau V, Floresco SB.
Neuropsychopharmacology. 2012 Sep;37(10):2194-209. doi: 10.1038/npp.2012.69. Epub 2012 May 9.

43. Separate prefrontal-subcortical circuits mediate different components of risk-based decision making.
St Onge JR, Stopper CM, Zahm DS, Floresco SB.
J Neurosci. 2012 Feb 22;32(8):2886-99. doi: 10.1523/JNEUROSCI.5625-11.2012.

42. NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear.
Dalton GL, Wu DC, Wang YT, Floresco SB, Phillips AG.
Neuropharmacology. 2012 Feb;62(2):797-806. doi: 10.1016/j.neuropharm.2011.09.001. Epub 2011 Sep 10.

41. Estradiol modulates effort-based decision making in female rats.
Uban KA, Rummel J, Floresco SB, Galea LA.
Neuropsychopharmacology. 2012 Jan;37(2):390-401. doi: 10.1038/npp.2011.176. Epub 2011 Aug 31.

40. Emerging, reemerging, and forgotten brain areas of the reward circuit: Notes from the 2010 Motivational Neural Networks conference.
McGinty VB, Hayden BY, Heilbronner SR, Dumont EC, Graves SM, Mirrione MM, du Hoffmann J, Sartor GC, España RA, Millan EZ, Difeliceantonio AG, Marchant NJ, Napier TC, Root DH, Borgland SL, Treadway MT, Floresco SB, McGinty JF, Haber S.
Behav Brain Res. 2011 Nov 20;225(1):348-57. doi: 10.1016/j.bbr.2011.07.036. Epub 2011 Jul 26. Review.

39. Repeated amphetamine exposure disrupts dopaminergic modulation of amygdala-prefrontal circuitry and cognitive/emotional functioning.
Tse MT, Cantor A, Floresco SB.
J Neurosci. 2011 Aug 3;31(31):11282-94. doi: 10.1523/JNEUROSCI.1810-11.2011.

38. Blockade of NMDA GluN2B receptors selectively impairs behavioral flexibility but not initial discrimination learning.
Dalton GL, Ma LM, Phillips AG, Floresco SB.
Psychopharmacology (Berl). 2011 Aug;216(4):525-35. doi: 10.1007/s00213-011-2246-z. Epub 2011 Mar 8.

37. Dissociable contributions by prefrontal D1 and D2 receptors to risk-based decision making.
St Onge JR, Abhari H, Floresco SB.
J Neurosci. 2011 Jun 8;31(23):8625-33. doi: 10.1523/JNEUROSCI.1020-11.2011.

36. Reducing prefrontal gamma-aminobutyric acid activity induces cognitive, behavioral, and dopaminergic abnormalities that resemble schizophrenia.
Enomoto T, Tse MT, Floresco SB.
Biol Psychiatry. 2011 Mar 1;69(5):432-41. doi: 10.1016/j.biopsych.2010.09.038. Epub 2010 Dec 10.

35. Contributions of the nucleus accumbens and its subregions to different aspects of risk-based decision making.
Stopper CM, Floresco SB.
Cogn Affect Behav Neurosci. 2011 Mar;11(1):97-112. doi: 10.3758/s13415-010-0015-9.

34. Pharmacological enhancement of memory and executive functioning in laboratory animals.
Floresco SB, Jentsch JD.
Neuropsychopharmacology. 2011 Jan;36(1):227-50. doi: 10.1038/npp.2010.158. Epub 2010 Sep 15. Review.

33. Prefrontal cortical contribution to risk-based decision making.
St Onge JR, Floresco SB.
Cereb Cortex. 2010 Aug;20(8):1816-28. doi: 10.1093/cercor/bhp250. Epub 2009 Nov 5.

32. Differential effects of dopaminergic manipulations on risky choice.
St Onge JR, Chiu YC, Floresco SB.
Psychopharmacology (Berl). 2010 Aug;211(2):209-21. doi: 10.1007/s00213-010-1883-y. Epub 2010 May 22.

31. Contributions of the orbitofrontal cortex to impulsive choice: interactions with basal levels of impulsivity, dopamine signalling, and reward-related cues.
Zeeb FD, Floresco SB, Winstanley CA.
Psychopharmacology (Berl). 2010 Jul;211(1):87-98. doi: 10.1007/s00213-010-1871-2. Epub 2010 Apr 29.

30. Abrupt transitions between prefrontal neural ensemble states accompany behavioral transitions during rule learning.
Durstewitz D, Vittoz NM, Floresco SB, Seamans JK.
Neuron. 2010 May 13;66(3):438-48. doi: 10.1016/j.neuron.2010.03.029.

29. Differential effects on effort discounting induced by inactivations of the nucleus accumbens core or shell.
Ghods-Sharifi S, Floresco SB.
Behav Neurosci. 2010 Apr;124(2):179-91. doi: 10.1037/a0018932.

28. Neural circuits subserving behavioral flexibility and their relevance to schizophrenia.
Floresco SB, Zhang Y, Enomoto T.
Behav Brain Res. 2009 Dec 7;204(2):396-409. doi: 10.1016/j.bbr.2008.12.001. Epub 2008 Dec 6. Review.

27. Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis.
Hill MN, McLaughlin RJ, Morrish AC, Viau V, Floresco SB, Hillard CJ, Gorzalka BB.
Neuropsychopharmacology. 2009 Dec;34(13):2733-45. doi: 10.1038/npp.2009.114. Epub 2009 Aug 26.

26. Regional specificity in dopamine signaling during reward-related learning (Commentary on Aragona et al.).
Floresco SB.
Eur J Neurosci. 2009 Nov;30(10):1888. doi: 10.1111/j.1460-9568.2009.7036.x. Epub 2009 Nov 11.

25. Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers.
Borgland SL, Chang SJ, Bowers MS, Thompson JL, Vittoz N, Floresco SB, Chou J, Chen BT, Bonci A.
J Neurosci. 2009 Sep 9;29(36):11215-25. doi: 10.1523/JNEUROSCI.6096-08.2009.

24. Perturbations in different forms of cost/benefit decision making induced by repeated amphetamine exposure.
Floresco SB, Whelan JM.
Psychopharmacology (Berl). 2009 Aug;205(2):189-201. doi: 10.1007/s00213-009-1529-0. Epub 2009 Apr 14.

23. Ventral striatal dopamine modulation of different forms of behavioral flexibility.
Haluk DM, Floresco SB.
Neuropsychopharmacology. 2009 Jul;34(8):2041-52. doi: 10.1038/npp.2009.21. Epub 2009 Mar 4.

22. Disruptions in spatial working memory, but not short-term memory, induced by repeated ketamine exposure.
Enomoto T, Floresco SB.
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Jun 15;33(4):668-75. doi: 10.1016/j.pnpbp.2009.03.013. Epub 2009 Mar 21.

21. Fundamental contribution by the basolateral amygdala to different forms of decision making.
Ghods-Sharifi S, St Onge JR, Floresco SB.
J Neurosci. 2009 Apr 22;29(16):5251-9. doi: 10.1523/JNEUROSCI.0315-09.2009.

20. Dopaminergic modulation of risk-based decision making.
St Onge JR, Floresco SB.
Neuropsychopharmacology. 2009 Feb;34(3):681-97. doi: 10.1038/npp.2008.121. Epub 2008 Jul 30.

19. Cortico-limbic-striatal circuits subserving different forms of cost-benefit decision making.
Floresco SB, St Onge JR, Ghods-Sharifi S, Winstanley CA.
Cogn Affect Behav Neurosci. 2008 Dec;8(4):375-89. doi: 10.3758/CABN.8.4.375. Review.

18. Disruption of AMPA receptor endocytosis impairs the extinction, but not acquisition of learned fear.
Dalton GL, Wang YT, Floresco SB, Phillips AG.
Neuropsychopharmacology. 2008 Sep;33(10):2416-26. Epub 2007 Nov 28.

17. Dopaminergic and glutamatergic regulation of effort- and delay-based decision making.
Floresco SB, Tse MT, Ghods-Sharifi S.
Neuropsychopharmacology. 2008 Jul;33(8):1966-79. Epub 2007 Sep 5.

16. Inactivation of the medial prefrontal cortex of the rat impairs strategy set-shifting, but not reversal learning, using a novel, automated procedure.
Floresco SB, Block AE, Tse MT.
Behav Brain Res. 2008 Jun 26;190(1):85-96. doi: 10.1016/j.bbr.2008.02.008. Epub 2008 Feb 15.

15. Opposing roles for the nucleus accumbens core and shell in cue-induced reinstatement of food-seeking behavior.
Floresco SB, McLaughlin RJ, Haluk DM.
Neuroscience. 2008 Jun 26;154(3):877-84. doi: 10.1016/j.neuroscience.2008.04.004. Epub 2008 Apr 9.

14. Differential effects of inactivation of the orbitofrontal cortex on strategy set-shifting and reversal learning.
Ghods-Sharifi S, Haluk DM, Floresco SB.
Neurobiol Learn Mem. 2008 May;89(4):567-73. Epub 2007 Nov 28.

13. Dopaminergic regulation of limbic-striatal interplay.
Floresco SB.
J Psychiatry Neurosci. 2007 Nov;32(6):400-11. Review.

12. Thalamic-prefrontal cortical-ventral striatal circuitry mediates dissociable components of strategy set shifting.
Block AE, Dhanji H, Thompson-Tardif SF, Floresco SB.
Cereb Cortex. 2007 Jul;17(7):1625-36. Epub 2006 Sep 8.

11. The role of different subregions of the basolateral amygdala in cue-induced reinstatement and extinction of food-seeking behavior.
McLaughlin RJ, Floresco SB.
Neuroscience. 2007 Jun 8;146(4):1484-94. Epub 2007 Apr 20.

10. Regulation of firing of dopaminergic neurons and control of goal-directed behaviors.
Grace AA, Floresco SB, Goto Y, Lodge DJ.
Trends Neurosci. 2007 May;30(5):220-7. Epub 2007 Apr 2. Review.

9. Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway.
Floresco SB, Tse MT.
J Neurosci. 2007 Feb 21;27(8):2045-57.

8. Amygdala-prefrontal cortical circuitry regulates effort-based decision making.
Floresco SB, Ghods-Sharifi S.
Cereb Cortex. 2007 Feb;17(2):251-60. Epub 2006 Feb 22.

7. Systemic and local administration of estradiol into the prefrontal cortex or hippocampus differentially alters working memory.
Sinopoli KJ, Floresco SB, Galea LA.
Neurobiol Learn Mem. 2006 Nov;86(3):293-304. Epub 2006 May 26.

6. Mesocortical dopamine modulation of executive functions: beyond working memory.
Floresco SB, Magyar O.
Psychopharmacology (Berl). 2006 Nov;188(4):567-85. Epub 2006 May 3. Review.

5. Alterations in behavioral flexibility by cannabinoid CB1 receptor agonists and antagonists.
Hill MN, Froese LM, Morrish AC, Sun JC, Floresco SB.
Psychopharmacology (Berl). 2006 Aug;187(2):245-59. Epub 2006 Jun 3.

4. Dissociable roles for the nucleus accumbens core and shell in regulating set shifting.
Floresco SB, Ghods-Sharifi S, Vexelman C, Magyar O.
J Neurosci. 2006 Mar 1;26(9):2449-57.

3. Multiple dopamine receptor subtypes in the medial prefrontal cortex of the rat regulate set-shifting.
Floresco SB, Magyar O, Ghods-Sharifi S, Vexelman C, Tse MT.
Neuropsychopharmacology. 2006 Feb;31(2):297-309.

2. Developing predictive animal models and establishing a preclinical trials network for assessing treatment effects on cognition in schizophrenia.
Floresco SB, Geyer MA, Gold LH, Grace AA.
Schizophr Bull. 2005 Oct;31(4):888-94. Epub 2005 Aug 3.

1. Magnitude of dopamine release in medial prefrontal cortex predicts accuracy of memory on a delayed response task.
Phillips AG, Ahn S, Floresco SB.
J Neurosci. 2004 Jan 14;24(2):547-53.